Endocrine Abstracts

Fetal ultrasonography is recommended in pregnant women with elevated TSH receptor antibodies (TRAK) or treated with antithyroid drugs in attempt to recognize fetal thyroid dysfunction. We report two cases of pregnant women with Graves’ disease in whom fetal thyroid ultrasonography was especially useful in diagnosing child involvement.A 33-year-old woman at 30-week pregnancy with 3-months history of hyperthyroidism treated with propylothiouracil (PTU...

The aim of the study was to compare efficacy and tolerability of systemic corticotherapy alone to corticotherapy combined with orbital radiotherapy in severe active Graves’ ophthalmopathy. We studied 905 patients, aged 35–73 years (mean 58.2 ±12), with clinical activity score above 4 and ATA class 3c to 6. Therapeutic outcome was assessed by change in ophthalmopathy index. For 4 weeks all subjects received corticotherapy: 869 - oral prednisone 60–100 mg dai...

Aim: Estimation of the effectiveness of a single low dose 0.05 mg rhTSH in increasing radioiodine uptake (RAIU) before 131I therapy for multinodular toxic goiter with low initial RAIU.Patients: 24 patients (21 women, 3 men) with multinodular toxic goiter without prior antithyroid drug therapy. The initial 24 h RAIU was 21.1±8.44%; range, 6–39% and thyroid volume 64.14±22.49 ml; range, 24.8–109 ml.Meth...